Thrombopoietin in Regulation
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منابع مشابه
Optimized Cytoplasmic Expression of Water Soluble Human Thrombopoietin in Modified Bacterial Strain
Background: Thrombopoietin is a glycoprotein produced by liver and kidney which is responsible for regulating the platelet production. Thrombopoietin is a key ligand with impact on regulating the self-renewal of Hematopoietic stem cells and the regulation of Megakaryocytes progenitors. Previous studies have indicated that only N-terminal domain of this protein has receptor promoting ability. Th...
متن کاملThrombopoietin.
By Shirley Ebbe I T HAS BEEN CLEAR for almost 20 years that platelet production is subject to homeostatic regulatory mechanisms that result in stimulation when the platelet count is li w’ and suppression when it is high.2 In spite of elapsed time, the physiologic processes that are involved in those regulatory mechanisms are not clear. Thrombocytopoiesis may be regulated by a humoral thrombopoi...
متن کاملBone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation.
Production of blood cells is regulated by the interplay of various cytokines and bone marrow stromal cells. Recently, a ligand for the orphan receptor Mpl was identified as thrombopoietin (TPO), which specifically regulates megakaryocyte differentiation, and it was reported to be expressed mainly in liver and kidney. As it was found that thrombopoietin is also produced in bone marrow stromal ce...
متن کاملGene cloning and expression of soluble thrombopoietin functional domain by harnessing Rosetta-gami expression system
Background: Thrombopoietin (TPO) is an important cytokine that has a critical role in regulating hematopoietic stem cells (HSCs) proliferation and megakaryocyte differentiation. Because of scares amount of this protein in human plasma, in many biotechnological centers around the world, recombinant production of this protein has been carried out. This study was aiming to gene cloning and express...
متن کاملHEMATOPOIESIS AND STEM CELLS BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling
Activin A, BMP2, and BMP4, 3 members of the transforming growth factorfamily, are involved in the regulation of hematopoiesis. Here, we explored the role of these molecules in human megakaryopoiesis using an in vitro serum-free assay. Our results highlight for the first time that, in the absence of thrombopoietin, BMP4 is able to induce CD34 progenitor differentiation into megakaryocytes throug...
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تاریخ انتشار 2017